Inhibiting phosphoinositide 3-kinases.
نویسندگان
چکیده
ISSN: 1538-4047 (Print) 1555-8576 (Online) Journal homepage: http://www.tandfonline.com/loi/kcbt20 Inhibiting phosphoinositide 3-kinases Yardena Samuels, Jiuxiang Zhu & Christoph Lengauer To cite this article: Yardena Samuels, Jiuxiang Zhu & Christoph Lengauer (2005) Inhibiting phosphoinositide 3-kinases, Cancer Biology & Therapy, 4:5, 546-547, DOI: 10.4161/cbt.4.5.1669 To link to this article: https://doi.org/10.4161/cbt.4.5.1669
منابع مشابه
Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment.
There is extensive evidence from the molecular and genomic analysis of human cancers that the PI 3-kinase (phosphoinositide 3-kinase)-Akt/PKB (protein kinase B) pathway is deregulated in malignant progression. Furthermore, the causal involvement of PI 3-kinase is supported by gene-knockout mouse models. Prototype inhibitors show evidence of anticancer activity in vitro and in vivo animal models...
متن کاملCharacterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
PDK1 (3-phosphoinositide-dependent protein kinase 1) activates a group of protein kinases belonging to the AGC [PKA (protein kinase A)/PKG (protein kinase G)/PKC (protein kinase C)]-kinase family that play important roles in mediating diverse biological processes. Many cancer-driving mutations induce activation of PDK1 targets including Akt, S6K (p70 ribosomal S6 kinase) and SGK (serum- and glu...
متن کاملRegulation of membrane traffic by phosphoinositide 3-kinases.
Phosphoinositide (PI) 3-kinases control essential cellular functions such as cytoskeletal dynamics, signal transduction and membrane trafficking. FYVE, PX and PH domains mediate the binding of effector proteins to the lipid products of PI 3-kinases. Recent studies have provided significant insights into the roles of PI 3-kinases, their catalytic products and their downstream effectors in membra...
متن کاملIgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts.
The human IgA Fc receptor (FcalphaR, CD89) triggers several important physiological functions, including phagocytosis, NADPH oxidase activation and antigen presentation. Efforts are underway to delineate FcalphaR signal-transduction pathways that control these functions. In a previous study, we demonstrated that cross-linking of FcalphaR increased its partitioning into membrane glycolipid rafts...
متن کاملPhosphoinositide 3-kinases and the regulation of platelet function.
A clear understanding of the role of PI (phosphoinositide) 3-kinases in supporting the haemostatic function of platelets has been slow to evolve. In fact, insight into the roles of individual PI 3-kinase isoforms in platelet function remains rudimentary. However, based on in vitro studies using wortmannin and LY294002, there is evidence for an important role for PI 3-kinases in regulating a bro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer biology & therapy
دوره 4 5 شماره
صفحات -
تاریخ انتشار 2005